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東海大學奈米科技研究中心-中心成員-前瞻系統智慧發展組-謝明麗 教授兼系主任

謝明麗 教授兼系主任

信箱:mhsieh@thu.edu.tw
個人網站:http://biology.thu.edu.tw/people/bio.php?PID=19
分機:32443
 

學歷

美國加州大學洛杉磯分校生化博士

經歷

東海大學生命科學研究中心主任(2012-)
東海大學生命科學系教授(2003-)
中山醫學大學生命科學系系主任(2001-2002)
Fox Chase 癌症中心(2001)
中山醫學大學生命科學系教授
(2000-2003)

專長

神經退化性疾病、分子醫學、轉錄調控機制

計畫

105學年度
新穎的葡萄糖代謝機制在大腸癌上的治療策略-新穎的葡萄糖代謝機制在大腸癌上的治療策略(2/3) (科技部)
104學年度
碳酸酐酶第八型在人類神經肌肉疾病的轉錄調控和保護功能機制分析:利用細胞和小鼠的研究 (科技部)
新穎的葡萄糖代謝機制在大腸癌上的治療策略-新穎的葡萄糖代謝機制在大腸癌上的治療策略(1/3) (科技部)
103學年度
碳酸酐脢第八型在運動協調及癌變過程的角色研究 (科技部)
102學年度
野生型和突變型碳酸酐脢第八型在神經肌肉退化性疾病的分子與功能研究 : 使用神經細胞與動物模式的研究 (國科會)
101學年度
人類碳酸酐酶相關蛋白在遺傳性神經肌肉疾病中的分子與功能分析:以細胞與斑馬魚模式之研究 (國科會)
100學年度
以細胞與斑馬魚模式探討CA8在遺傳性共濟失調症中的角色
97學年度
以細胞與果蠅模式研究熱休克蛋白27在粒線體疾病中的角色 (國科會)
96學年度
小腦脊髓運動失調第三型/馬卡多-喬瑟夫疾病分子機制及治療性化合物測試 (國科會)
Cyclophilin A 及氧化LDL在人類血管疾病之應用

期刊

(50). Tze-Kai Wang, Yu-Ming Lin, Che-Min Lo, Chih-Hsin Tang, Chieh-Lin Jerry Teng, Wei-Ting Chao, Min-Huan Wu, Chin-San Liu, Mingli Hsieh*., 2015, Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells.,Tumor Biology (SCI)
(49). Tsai SF, Su CW, Wu MJ, Chen CH, Fu CP, Liu CS, Hsieh M*., 2015, Urinary cyclophilin A as a new marker for diabetic nephropathy: A Cross-Sectional Analysis of diabetes mellitus., Medicine (Baltimore), 94, 42 (SCI)
(48). Min-Syuan Huang, Tze-Kai Wang, Yi-Wen Liu, Yi-Ting Li, Tang-Hao Chi, Chih-Wei Chou, Mingli Hsieh*., 2014, Roles of carbonic anhydrase 8 in neuronal cells and zebrafish., Biochimica et Biophysica Acta, 1840, 9, pp2829-2842 (SCI)
(47). Tze-Kai Wang, Che-Kun Cheng, Tang-Hao Chi, Yi-Shing Ma, Shi-Bei Wu, Yau-Huei Wei, Mingli Hsieh*., 2014, Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation., Biochemical Journal, 459, 1, pp149-160 (SCI)
(46). Jui-Chih Chang, Ko-Hung Liu, Yu-Chi Li, Shou-Jen Kou, Yau-Huei Wei, Chieh-Sen Chuang, Mingli Hsieh*, Chin-San Liu., 2013, Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery., Neurosignals, 21, 3-4, pp160-173 (SCI)
(45). Mingli Hsieh*, Wei-Hsiu Chang, Chi-Fu Hsu, Isao Nishimori, Cheng-Liang Kuo, Tomoko Minakuchi., 2013, Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3., Cerebellum, 12, 3, pp338-349 (SCI)
(44). Chih-Liang Tien, Chao-Hsiung Lin, Ting-Hui Lin, Feng-Chen Wen, Chien-Wei Su, Sheng-Seen Fan, Mingli Hsieh*., 2012, Secreted Cyclophilin A Induction during Embryo Implantation in a Model of Human Trophoblast-Endometrial Epithelium Interaction., European Journal of Obstetrics & Gynecology and Reproductive Biology, 164, 1,p p55-59 (SCI)
(43). Chen HF, Chen CY, Lin TH, Huang ZW, Chi TH, Ma YS, Wu SB, Wei YH, Hsieh M*. , 2012, The Protective Roles of Phosphorylated Heat Shock Protein 27 in Human Cells Harboring MERRF A8344G Mitochondrial DNA Mutation., FEBS Journal, 279, 16, pp2987-3001 (SCI)
(42). Chin-Yi Chen, Hsueh-Fu Chen, Siao-Jhen Gi, Tang-Hao Chi, Che-Kun Cheng, Chi-Fu Hsu, Yi-Shing Ma, Yau-Huei Wei, Chin-Shan Liu, Mingli Hsieh*., 2011, Decreased Heat Shock Protein 27 Expression and Altered Autophagy in Human Cells harboring A8344G Mitochondrial DNA Mutation., Mitochondrion, 11, 5, pp739-749- (SCI)
(41). Chen, J., Chen, T. S., Ho, K. I. J., Tsai, T. H., Tsai, H. F., Hsieh, M*., Wang, T. S., 2011, A high dynamic range vector quantisation for compressing 2DGE images of different exposures., Imaging Science Journal, 59, 3, pp166-176 (SCI)
(40). Cheng-Han Lin, Mingli Hsieh*, Seng-Sheen Fan., 2011, The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein., FEBS Letters, 585, 3, pp523-530 (SCI)
(39). Ya-Chun Yu, Chen-Ling Kuo, Wen-Ling Cheng, Chin-San Liu, Mingli Hsieh*., 2009, Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease., Journal of Neurosicence Research, 87, 8, pp1884-1891 (SCI)
(38). Wei-Hsiu Chang, Chih-Liang Tien, Tzu-Jung Chen, Nobuyuki Nukina, Mingli Hsieh*., 2009, Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease., Neuroscience Letters, 454, 2, pp152-156 (SCI)
(37). Lin YS, Hsieh M*, Lee YJ, Liu KL, Lin TH., 2008, AH23848 accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells., Nitric Oxide: Biology and Chemistry, 18, 2, pp93-104 (SCI)
(36). Chih-Liang Tien, Feng-Chen Wen, Mingli Hsieh*., 2008, The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability., Biochemical and Biophysical Research Communications, 365, 2, pp232-238 (SCI)
(35). Martins S, Calafell F, Gaspar C, Wong VC, Silveira I, Nicholson GA, Brunt ER, Tranebjaerg L, Stevanin G, Hsieh M*, Soong BW, Loureiro L, Dürr A, Tsuji S, Watanabe M, Jardim LB, Giunti P, Riess O, Ranum LP, Brice A, Rouleau GA, Coutinho P, Amorim A, Sequeiros J., 2007, Asian origin for the worldwide-spread mutational event in Machado-Joseph disease., Archives of neurology, 64, 10, pp1502-1508 (SCI)
(34). Chien-Jen Hung, Da-Huang Chen, Yi-Ting Shen, Yi-Chen Li, Yi-Wei Lin, Mingli Hsieh*, Chuan Li., 2007, Characterization of protein arginine methyltransferases in porcine brain., Journal of Biochemistry and Molecular Biology, 40, 5, pp617-624 (SCI)
(33). Tsai TH, Chen J, Chen TS, Chiou SF, Wang TS, Wu HC, Tsai HF, Hsieh M*, Chou MC, Li SY., 2006, Content-based progressive transmission of 2-DGE images., Imaging Science Journal, 54, 4, pp191-199 (SCI)
(32). Wei-Hsiu Chang, Cemal K Cemal, Yung-Hsiang Hsu, Cheng-Liang Kuo, Nobuyuki Nukina, Ming-Hong Chang, Hsiao-Tang Hu, Chuan Li, Mingli Hsieh*., 2005, Dynamic expression of Hsp27 in the presence of mutant ataxin-3., Biochemical and Biophysical Research Communications, 336, 1, pp258-267 (SCI)
(31). Hui-Fang Tsai, Shio Jean Lin, Chuan Li, Mingli Hsieh*., 2005, Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7., Biochemical and Biophysical Research Communications, 334, 4, pp1279-1286 (SCI)
(30). Liu CS1, Hsu HM, Cheng WL, Hsieh M*., 2005, Clinical and Molecular Events in Patients with Machado-Joseph Disease under Lamotrigine Therapy., Acta Neurologica Scandinavica, 111, 6, pp385-390 (SCI)
(29). Trang-Tiau Wu, Tsui-Wei Tsai, Chao-Ta Chu, Zen-Fung Lee, Chuan-Mao Hung, Ching-Chyuan Su, Shuan-Yow Li, Mingli Hsieh*, Chuan Li., 2005, Low RET mutation frequency and polymorphism analysis of the RET and EDNRB genes in patients with Hirschsprung disease in Taiwan., Journal of Human Genetics, 50, 4, pp168-174 (SCI)
(28). Chin-San Liu, Mingli Hsieh*, Yi-Yun Chen, Man-Chi Lo., 2005, Machado-Joseph Shoe., Movement Disorder, 20, 1, pp66-68 (SCI)
(27). Mingli Hsieh*, Hui-Fang Tsai, Wei-Hsiu Chang., 2005, HSP27 and cell death in Spinocerebellar Ataxia Type 3., Cerebellum, 4, 1, pp31-36 (SCI)
(26). Hui-Fang Tsai, Horng-Jyh Tsai, Mingli Hsieh*., 2004, Full-Length Expanded Ataxin-3 Enhances Mitochondrial Mediated Cell Death and Decreases Bcl-2 Expression in Human Neuroblastoma Cells., Biochemical and Biophysical Research Communications, 324, 4, pp1274-1282 (SCI)
(25). Da-Huang Chen, Kuan-Tsu Wu, Chien-Jen Hung, Mingli Hsieh*, Chuan Li., 2004, Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells., The Journal of Biochemistry, 136, 3, pp371-376 (SCI)
(24). Tsai HF, Liu CS, Leu TM, Wen FC, Lin SJ, Liu CC, Yang DK, Li C, Hsieh M*., 2004, Analysis of trinucleotide repeats in different SCA loci in spinocerebellar ataxia patients and in normal population of Taiwan., Acta Neurologica Scandinavica, 109, 5, pp355-360 (SCI)
(23). Feng-Chen Wen, Yen-Hsien Li, Hui-Fang Tsai, Chao-Hsiung Lin, Chuan Li, Chin-San Liu, Chong-Kuei Lii, Nobuyuki Nukina, Mingli Hsieh*., 2003, Down-Regulation of Heat Shock Protein 27 in Neuronal Cells and Non-neuronal cells Expressing Mutant Ataxin-3., FEBS Letters, 546, 2-3, pp307-314 (SCI)
(22). Tsai HF, Liu CS, Chen GD, Lin ML, Li C, Chen YY, Wang BT, Hsieh M*., 2003, Prenatal diagnosis of Machado-Joseph disease/ Spinocerebellar Ataxia Type 3 in Taiwan: early detection of expanded ataxin-3., Journal of Clinical Laboratory Analysis, 17, pp195-200 (SCI)
(21). Hung-Ming Huang, Ming F Tam, Tsuey-Chyi S Tam, Da-Huang Chen, Mingli Hsieh*, Chuan Li., 2002, Proteomic Analysis of stable Protein Methylation in Lymphoblastoid Cells., The Journal of Biochemistry, 132, 5, pp813-818 (SCI)
(20). Chia-Hui Lin, Hung-Ming Huang, Mingli Hsieh*, K Michael Pollard, Chuan Li. , 2002, Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase., Journal of Protein Chemistry, 21, 7, pp447-453 (SCI)
(19). Gaspar C, Lopes-Cendes I, Hayes S, Goto J, Arvidsson K, Dias A, Silveira I, Maciel P, Coutinho P, Lima M, Zhou YX, Soong BW, Watanabe M, Giunti P, Stevanin G, Riess O, Sasaki H, Hsieh M*, Nicholson GA, Brunt E, Higgins JJ, Lauritzen M, Tranebjaerg L, Volpini V, Wood N, Ranum L, Tsuji S, Brice A, Sequeiros J, Rouleau GA., 2001, Ancestral origins of the Machado-Joseph disease mutation: a worldwide haplotype study., American Journal of Human Genetics, 68, 2, pp523-528 (SCI)
(18). Liu CS, Sun MH, Kuo CL, Tsai CS, Lu HC, Tsai CF, Tsai CF, Hsieh M*., 2001, Molecular, Clinical Studies and Review in Spinocerebellar Ataxia Type 2., The Changhua Journal of Medicine, 6, pp107-112 (SCI)
(17). Lin C-H, Hsieh M*, Li Y-C, Li S-Y, Pearson DL, Pollard KM, Li C., 2000, Protein N-Arginine methylation in subcellular fractions of lymphoblastoid Cells., The Journal of Biochemistry, 128, 3, pp493-498 (SCI)
(16). Hsieh M* , Lin SJ, Chen JF, Lin HM, Hsiao KM, Li SY, Li C, Tsai CJ., 2000, Identification of the spinocerebellar ataxia type 7 mutation in Taiwan: application of PCR-based Southern blot., Journal of Neurology, 247, 8, pp623-629 (SCI)
(15). Hsieh M*, Chiu MH, Lin YH, Lu TM, Li SY, Li C., 2000, Distribution of CAG repeat size in the Dentatorubal and Pallidoluysian Atrophy (DRPLA) gene in a normal population in Taiwan., Proceedings of the National Science Council, 24, pp76-80 (SCI)
(14). Hsieh M*, Li SY, Tsai CJ, Chen YY, Liu CS, Chang CY, Ro LS, Chen DF, Chen SS, Li C., 1999, Identification of five Spinocerebellar Ataxia type 2 pedigrees in patients with autosomal dominant cerebellar ataxia in Taiwan., Acta Neurologica Scandinavica, 100, 3, pp189-194 (SCI)
(13). Hsieh M*, Hsu HM, Hwang SF , Wen FC, Yu JS, Wen CC, Li C., 1999, The hydrophobic heptad repeat in Region III of Escherichia coli transcription factor sigma 54 is essential for core RNA polymerase binding., Microbiology-UK, 145, pp3081-3088 (SCI)
(12). Ai LS, Lin CH., Hsieh M, Li C., 1999, Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin., Proceedings of the National Science Council, 23, pp175-180 (SCI)
(11). Hsieh M*, Li SY, Chen YY, Tsai CJ, Lin ML, Li C, Wu MJ., 1999, A non-radioactive PCR method for diagnosis of Machado-Joseph Disease., Journal of the Formosan Medical Association, 98, pp705-707 (SCI)
(10). Wu MJ, Chow LW, Hsieh M*., 1998, Amplification of GAA/TTC triplet repeat in vitro: preferential expansion of (TTC)n strand.,Biochimica et Biophysica Acta, 1407, 2, pp155-162 (SCI)
(9). Li C, Ai LS, Lin CH., Hsieh M*, Li YC, Li SY., 1998, Protein-N-arginine methylation in adenosine dialdehyde treated lymphoblastoid cells., 351, pp53-59 (SCI)
(8). Hsieh M*, Tsai HF, Lu TM, Yang CY, Wu HM, Li SY., 1997, Studies of the CAG repeat in the Machado-Joseph disease gene in Taiwan., Human Genetics, 100, 2, pp155-162 (SCI)
(7). Hsieh M*, Yang CY, Tsai HF, Li C, Chen YY, Li SY., 1997, The CAG repeats number of spinocerebellar ataxia type 1 gene in normal Taiwanese and in patients with dominant inherited ataxia., Proceedings of the National Science Council, 21, pp91-95 (SCI)
(6). Li C , Wu P-Y, Hseih M*., 1997, Growth-phase-dependent transcriptional regulation of the pcm and surE gene required for stationary-phase survival of Escherichia coli., Microbiology-UK, 143, pp3513-3520 (SCI)
(5). Wang JT, Syed A, Hsieh M*, Gralla JD., 1995, Converting Escherichia coli RNA polymerase into an enhancer-responsive enzyme: role of an NH2-terminal leucine patch in sigma 54., Science, 270, pp992-994 (SCI)
(4). Hsieh M*, Tintut Y, Gralla JD., 1994, Functional roles of the glutamines within the glutamine-rich region of transcription factor sigma 54., Journal of Biological Chemistry, 269, pp373-378 (SCI)
(3). Hsieh M* and Gralla JD., 1994, Analysis of the N-terminal leucine heptad and hexad repeats of sigma 54., Journal of Molecular Biology, 239, 1, pp15-24 (SCI)
(2). Tintut Y, Wong CW, Jiang Y, Hsieh M*, Gralla JD., 1994, RNA polymerase binding using a strong acidic hydrophobic-repeat region of sigma 54., PNAS, 91, pp2120-2124 (SCI)
(1). Hsieh M*, Cheng MC, and Peng SM., 1988, New Coupling recation of 0-phenylenediamine catalyzed by Mn(II) ion., Inorganica Chimica Acta, 145, pp1-2 (SCI)

 

學歷

美國加州大學洛杉磯分校生化博士

經歷

東海大學生命科學研究中心主任(2012-)
東海大學生命科學系教授(2003-)
中山醫學大學生命科學系系主任(2001-2002)
Fox Chase 癌症中心(2001)
中山醫學大學生命科學系教授
(2000-2003)

專長

神經退化性疾病、分子醫學、轉錄調控機制

計畫

105學年度
新穎的葡萄糖代謝機制在大腸癌上的治療策略-新穎的葡萄糖代謝機制在大腸癌上的治療策略(2/3) (科技部)
104學年度
碳酸酐酶第八型在人類神經肌肉疾病的轉錄調控和保護功能機制分析:利用細胞和小鼠的研究 (科技部)
新穎的葡萄糖代謝機制在大腸癌上的治療策略-新穎的葡萄糖代謝機制在大腸癌上的治療策略(1/3) (科技部)
103學年度
碳酸酐脢第八型在運動協調及癌變過程的角色研究 (科技部)
102學年度
野生型和突變型碳酸酐脢第八型在神經肌肉退化性疾病的分子與功能研究 : 使用神經細胞與動物模式的研究 (國科會)
101學年度
人類碳酸酐酶相關蛋白在遺傳性神經肌肉疾病中的分子與功能分析:以細胞與斑馬魚模式之研究 (國科會)
100學年度
以細胞與斑馬魚模式探討CA8在遺傳性共濟失調症中的角色
97學年度
以細胞與果蠅模式研究熱休克蛋白27在粒線體疾病中的角色 (國科會)
96學年度
小腦脊髓運動失調第三型/馬卡多-喬瑟夫疾病分子機制及治療性化合物測試 (國科會)
Cyclophilin A 及氧化LDL在人類血管疾病之應用

期刊

(50). Tze-Kai Wang, Yu-Ming Lin, Che-Min Lo, Chih-Hsin Tang, Chieh-Lin Jerry Teng, Wei-Ting Chao, Min-Huan Wu, Chin-San Liu, Mingli Hsieh*., 2015, Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells.,Tumor Biology (SCI)
(49). Tsai SF, Su CW, Wu MJ, Chen CH, Fu CP, Liu CS, Hsieh M*., 2015, Urinary cyclophilin A as a new marker for diabetic nephropathy: A Cross-Sectional Analysis of diabetes mellitus., Medicine (Baltimore), 94, 42 (SCI)
(48). Min-Syuan Huang, Tze-Kai Wang, Yi-Wen Liu, Yi-Ting Li, Tang-Hao Chi, Chih-Wei Chou, Mingli Hsieh*., 2014, Roles of carbonic anhydrase 8 in neuronal cells and zebrafish., Biochimica et Biophysica Acta, 1840, 9, pp2829-2842 (SCI)
(47). Tze-Kai Wang, Che-Kun Cheng, Tang-Hao Chi, Yi-Shing Ma, Shi-Bei Wu, Yau-Huei Wei, Mingli Hsieh*., 2014, Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation., Biochemical Journal, 459, 1, pp149-160 (SCI)
(46). Jui-Chih Chang, Ko-Hung Liu, Yu-Chi Li, Shou-Jen Kou, Yau-Huei Wei, Chieh-Sen Chuang, Mingli Hsieh*, Chin-San Liu., 2013, Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery., Neurosignals, 21, 3-4, pp160-173 (SCI)
(45). Mingli Hsieh*, Wei-Hsiu Chang, Chi-Fu Hsu, Isao Nishimori, Cheng-Liang Kuo, Tomoko Minakuchi., 2013, Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3., Cerebellum, 12, 3, pp338-349 (SCI)
(44). Chih-Liang Tien, Chao-Hsiung Lin, Ting-Hui Lin, Feng-Chen Wen, Chien-Wei Su, Sheng-Seen Fan, Mingli Hsieh*., 2012, Secreted Cyclophilin A Induction during Embryo Implantation in a Model of Human Trophoblast-Endometrial Epithelium Interaction., European Journal of Obstetrics & Gynecology and Reproductive Biology, 164, 1,p p55-59 (SCI)
(43). Chen HF, Chen CY, Lin TH, Huang ZW, Chi TH, Ma YS, Wu SB, Wei YH, Hsieh M*. , 2012, The Protective Roles of Phosphorylated Heat Shock Protein 27 in Human Cells Harboring MERRF A8344G Mitochondrial DNA Mutation., FEBS Journal, 279, 16, pp2987-3001 (SCI)
(42). Chin-Yi Chen, Hsueh-Fu Chen, Siao-Jhen Gi, Tang-Hao Chi, Che-Kun Cheng, Chi-Fu Hsu, Yi-Shing Ma, Yau-Huei Wei, Chin-Shan Liu, Mingli Hsieh*., 2011, Decreased Heat Shock Protein 27 Expression and Altered Autophagy in Human Cells harboring A8344G Mitochondrial DNA Mutation., Mitochondrion, 11, 5, pp739-749- (SCI)
(41). Chen, J., Chen, T. S., Ho, K. I. J., Tsai, T. H., Tsai, H. F., Hsieh, M*., Wang, T. S., 2011, A high dynamic range vector quantisation for compressing 2DGE images of different exposures., Imaging Science Journal, 59, 3, pp166-176 (SCI)
(40). Cheng-Han Lin, Mingli Hsieh*, Seng-Sheen Fan., 2011, The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein., FEBS Letters, 585, 3, pp523-530 (SCI)
(39). Ya-Chun Yu, Chen-Ling Kuo, Wen-Ling Cheng, Chin-San Liu, Mingli Hsieh*., 2009, Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease., Journal of Neurosicence Research, 87, 8, pp1884-1891 (SCI)
(38). Wei-Hsiu Chang, Chih-Liang Tien, Tzu-Jung Chen, Nobuyuki Nukina, Mingli Hsieh*., 2009, Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease., Neuroscience Letters, 454, 2, pp152-156 (SCI)
(37). Lin YS, Hsieh M*, Lee YJ, Liu KL, Lin TH., 2008, AH23848 accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells., Nitric Oxide: Biology and Chemistry, 18, 2, pp93-104 (SCI)
(36). Chih-Liang Tien, Feng-Chen Wen, Mingli Hsieh*., 2008, The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability., Biochemical and Biophysical Research Communications, 365, 2, pp232-238 (SCI)
(35). Martins S, Calafell F, Gaspar C, Wong VC, Silveira I, Nicholson GA, Brunt ER, Tranebjaerg L, Stevanin G, Hsieh M*, Soong BW, Loureiro L, Dürr A, Tsuji S, Watanabe M, Jardim LB, Giunti P, Riess O, Ranum LP, Brice A, Rouleau GA, Coutinho P, Amorim A, Sequeiros J., 2007, Asian origin for the worldwide-spread mutational event in Machado-Joseph disease., Archives of neurology, 64, 10, pp1502-1508 (SCI)
(34). Chien-Jen Hung, Da-Huang Chen, Yi-Ting Shen, Yi-Chen Li, Yi-Wei Lin, Mingli Hsieh*, Chuan Li., 2007, Characterization of protein arginine methyltransferases in porcine brain., Journal of Biochemistry and Molecular Biology, 40, 5, pp617-624 (SCI)
(33). Tsai TH, Chen J, Chen TS, Chiou SF, Wang TS, Wu HC, Tsai HF, Hsieh M*, Chou MC, Li SY., 2006, Content-based progressive transmission of 2-DGE images., Imaging Science Journal, 54, 4, pp191-199 (SCI)
(32). Wei-Hsiu Chang, Cemal K Cemal, Yung-Hsiang Hsu, Cheng-Liang Kuo, Nobuyuki Nukina, Ming-Hong Chang, Hsiao-Tang Hu, Chuan Li, Mingli Hsieh*., 2005, Dynamic expression of Hsp27 in the presence of mutant ataxin-3., Biochemical and Biophysical Research Communications, 336, 1, pp258-267 (SCI)
(31). Hui-Fang Tsai, Shio Jean Lin, Chuan Li, Mingli Hsieh*., 2005, Decreased expression of Hsp27 and Hsp70 in transformed lymphoblastoid cells from patients with spinocerebellar ataxia type 7., Biochemical and Biophysical Research Communications, 334, 4, pp1279-1286 (SCI)
(30). Liu CS1, Hsu HM, Cheng WL, Hsieh M*., 2005, Clinical and Molecular Events in Patients with Machado-Joseph Disease under Lamotrigine Therapy., Acta Neurologica Scandinavica, 111, 6, pp385-390 (SCI)
(29). Trang-Tiau Wu, Tsui-Wei Tsai, Chao-Ta Chu, Zen-Fung Lee, Chuan-Mao Hung, Ching-Chyuan Su, Shuan-Yow Li, Mingli Hsieh*, Chuan Li., 2005, Low RET mutation frequency and polymorphism analysis of the RET and EDNRB genes in patients with Hirschsprung disease in Taiwan., Journal of Human Genetics, 50, 4, pp168-174 (SCI)
(28). Chin-San Liu, Mingli Hsieh*, Yi-Yun Chen, Man-Chi Lo., 2005, Machado-Joseph Shoe., Movement Disorder, 20, 1, pp66-68 (SCI)
(27). Mingli Hsieh*, Hui-Fang Tsai, Wei-Hsiu Chang., 2005, HSP27 and cell death in Spinocerebellar Ataxia Type 3., Cerebellum, 4, 1, pp31-36 (SCI)
(26). Hui-Fang Tsai, Horng-Jyh Tsai, Mingli Hsieh*., 2004, Full-Length Expanded Ataxin-3 Enhances Mitochondrial Mediated Cell Death and Decreases Bcl-2 Expression in Human Neuroblastoma Cells., Biochemical and Biophysical Research Communications, 324, 4, pp1274-1282 (SCI)
(25). Da-Huang Chen, Kuan-Tsu Wu, Chien-Jen Hung, Mingli Hsieh*, Chuan Li., 2004, Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells., The Journal of Biochemistry, 136, 3, pp371-376 (SCI)
(24). Tsai HF, Liu CS, Leu TM, Wen FC, Lin SJ, Liu CC, Yang DK, Li C, Hsieh M*., 2004, Analysis of trinucleotide repeats in different SCA loci in spinocerebellar ataxia patients and in normal population of Taiwan., Acta Neurologica Scandinavica, 109, 5, pp355-360 (SCI)
(23). Feng-Chen Wen, Yen-Hsien Li, Hui-Fang Tsai, Chao-Hsiung Lin, Chuan Li, Chin-San Liu, Chong-Kuei Lii, Nobuyuki Nukina, Mingli Hsieh*., 2003, Down-Regulation of Heat Shock Protein 27 in Neuronal Cells and Non-neuronal cells Expressing Mutant Ataxin-3., FEBS Letters, 546, 2-3, pp307-314 (SCI)
(22). Tsai HF, Liu CS, Chen GD, Lin ML, Li C, Chen YY, Wang BT, Hsieh M*., 2003, Prenatal diagnosis of Machado-Joseph disease/ Spinocerebellar Ataxia Type 3 in Taiwan: early detection of expanded ataxin-3., Journal of Clinical Laboratory Analysis, 17, pp195-200 (SCI)
(21). Hung-Ming Huang, Ming F Tam, Tsuey-Chyi S Tam, Da-Huang Chen, Mingli Hsieh*, Chuan Li., 2002, Proteomic Analysis of stable Protein Methylation in Lymphoblastoid Cells., The Journal of Biochemistry, 132, 5, pp813-818 (SCI)
(20). Chia-Hui Lin, Hung-Ming Huang, Mingli Hsieh*, K Michael Pollard, Chuan Li. , 2002, Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase., Journal of Protein Chemistry, 21, 7, pp447-453 (SCI)
(19). Gaspar C, Lopes-Cendes I, Hayes S, Goto J, Arvidsson K, Dias A, Silveira I, Maciel P, Coutinho P, Lima M, Zhou YX, Soong BW, Watanabe M, Giunti P, Stevanin G, Riess O, Sasaki H, Hsieh M*, Nicholson GA, Brunt E, Higgins JJ, Lauritzen M, Tranebjaerg L, Volpini V, Wood N, Ranum L, Tsuji S, Brice A, Sequeiros J, Rouleau GA., 2001, Ancestral origins of the Machado-Joseph disease mutation: a worldwide haplotype study., American Journal of Human Genetics, 68, 2, pp523-528 (SCI)
(18). Liu CS, Sun MH, Kuo CL, Tsai CS, Lu HC, Tsai CF, Tsai CF, Hsieh M*., 2001, Molecular, Clinical Studies and Review in Spinocerebellar Ataxia Type 2., The Changhua Journal of Medicine, 6, pp107-112 (SCI)
(17). Lin C-H, Hsieh M*, Li Y-C, Li S-Y, Pearson DL, Pollard KM, Li C., 2000, Protein N-Arginine methylation in subcellular fractions of lymphoblastoid Cells., The Journal of Biochemistry, 128, 3, pp493-498 (SCI)
(16). Hsieh M* , Lin SJ, Chen JF, Lin HM, Hsiao KM, Li SY, Li C, Tsai CJ., 2000, Identification of the spinocerebellar ataxia type 7 mutation in Taiwan: application of PCR-based Southern blot., Journal of Neurology, 247, 8, pp623-629 (SCI)
(15). Hsieh M*, Chiu MH, Lin YH, Lu TM, Li SY, Li C., 2000, Distribution of CAG repeat size in the Dentatorubal and Pallidoluysian Atrophy (DRPLA) gene in a normal population in Taiwan., Proceedings of the National Science Council, 24, pp76-80 (SCI)
(14). Hsieh M*, Li SY, Tsai CJ, Chen YY, Liu CS, Chang CY, Ro LS, Chen DF, Chen SS, Li C., 1999, Identification of five Spinocerebellar Ataxia type 2 pedigrees in patients with autosomal dominant cerebellar ataxia in Taiwan., Acta Neurologica Scandinavica, 100, 3, pp189-194 (SCI)
(13). Hsieh M*, Hsu HM, Hwang SF , Wen FC, Yu JS, Wen CC, Li C., 1999, The hydrophobic heptad repeat in Region III of Escherichia coli transcription factor sigma 54 is essential for core RNA polymerase binding., Microbiology-UK, 145, pp3081-3088 (SCI)
(12). Ai LS, Lin CH., Hsieh M, Li C., 1999, Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin., Proceedings of the National Science Council, 23, pp175-180 (SCI)
(11). Hsieh M*, Li SY, Chen YY, Tsai CJ, Lin ML, Li C, Wu MJ., 1999, A non-radioactive PCR method for diagnosis of Machado-Joseph Disease., Journal of the Formosan Medical Association, 98, pp705-707 (SCI)
(10). Wu MJ, Chow LW, Hsieh M*., 1998, Amplification of GAA/TTC triplet repeat in vitro: preferential expansion of (TTC)n strand.,Biochimica et Biophysica Acta, 1407, 2, pp155-162 (SCI)
(9). Li C, Ai LS, Lin CH., Hsieh M*, Li YC, Li SY., 1998, Protein-N-arginine methylation in adenosine dialdehyde treated lymphoblastoid cells., 351, pp53-59 (SCI)
(8). Hsieh M*, Tsai HF, Lu TM, Yang CY, Wu HM, Li SY., 1997, Studies of the CAG repeat in the Machado-Joseph disease gene in Taiwan., Human Genetics, 100, 2, pp155-162 (SCI)
(7). Hsieh M*, Yang CY, Tsai HF, Li C, Chen YY, Li SY., 1997, The CAG repeats number of spinocerebellar ataxia type 1 gene in normal Taiwanese and in patients with dominant inherited ataxia., Proceedings of the National Science Council, 21, pp91-95 (SCI)
(6). Li C , Wu P-Y, Hseih M*., 1997, Growth-phase-dependent transcriptional regulation of the pcm and surE gene required for stationary-phase survival of Escherichia coli., Microbiology-UK, 143, pp3513-3520 (SCI)
(5). Wang JT, Syed A, Hsieh M*, Gralla JD., 1995, Converting Escherichia coli RNA polymerase into an enhancer-responsive enzyme: role of an NH2-terminal leucine patch in sigma 54., Science, 270, pp992-994 (SCI)
(4). Hsieh M*, Tintut Y, Gralla JD., 1994, Functional roles of the glutamines within the glutamine-rich region of transcription factor sigma 54., Journal of Biological Chemistry, 269, pp373-378 (SCI)
(3). Hsieh M* and Gralla JD., 1994, Analysis of the N-terminal leucine heptad and hexad repeats of sigma 54., Journal of Molecular Biology, 239, 1, pp15-24 (SCI)
(2). Tintut Y, Wong CW, Jiang Y, Hsieh M*, Gralla JD., 1994, RNA polymerase binding using a strong acidic hydrophobic-repeat region of sigma 54., PNAS, 91, pp2120-2124 (SCI)
(1). Hsieh M*, Cheng MC, and Peng SM., 1988, New Coupling recation of 0-phenylenediamine catalyzed by Mn(II) ion., Inorganica Chimica Acta, 145, pp1-2 (SCI)